DRAP: a database of rheumatoid arthritis-related polymorphisms
Abstract
Rheumatoid arthritis (RA) is an autoimmune disease that has a complex genetic basis. Therefore, it is very important to explore the genetic background of RA. The extensive recent application of polymorphic genetic markers, especially single nucleotide polymorphisms, has presented us with a large quantity of genetic data. In this study, we developed the Database of Rheumatoid Arthritis-related Polymorphisms (DRAP), to integrate all the RA-related genetic polymorphisms and provide a useful resource for researchers. We manually extracted the RA-related polymorphisms from 522 published reports, including RA susceptibility loci, polymorphisms associated with particular clinical features of RA, polymorphisms associated with drug response in RA, and polymorphisms associated with a higher risk of cardiovascular disease in RA. Currently, DRAP contains 2,865 polymorphisms that are associated with 517 genes and refer to 51 populations. The detailed information extracted from the literature includes basic information about the articles (e.g., PubMed ID, title, and abstract), population information (e.g., race, geographic area, and sample size), and polymorphism information (e.g., polymorphism name, gene, genotype, odds ratio and 95% confidence interval, P-value, and risk allele). Meanwhile, useful annotations, such as hyperlinks to dbSNP, GenBank, UCSC, Gene Ontology, and KEGG pathway, are included. In addition, a tool for meta-analysis was developed to summarize the results of multiple studies.
Supplementary File 1. Genes and genetic regions that have the strongest association with RA susceptibility.
Supplementary File 2. The statistical information about repeat times of populations.
Supplementary File 3. We performed GO term enrichment analysis of RA-related genes (at least one polymorphism with a P-value less than 0.05) based on Fisher’s exact test (p-value<0.01). The significant GO terms are listed in the following table.