Detail
| RLID: |
RLID00000543 |
| RNA Symbol: |
LRPPRC |
| RNA Category: |
mRNA |
| Organism: |
Homo sapiens |
| Aliase: |
LSFC, GP130, LRP130, CLONE-23970 |
| Subcellular Localization: |
| Localization |
Tissue |
Validated Method |
PMID |
| Endoplasmic reticulum |
HeLa cell |
In situ hybridization |
15081402 |
|
Description: To further analyze the subcellular localization of LRP130, a nuclear/ER fraction was fractionated into the nucleoplasm (NP) and nuclear envelope (NE)/ER, and the latter was further separated into outer nuclear membrane (ONM)/ER and inner nuclear membrane (INM) by treatment with Triton X-100. LRP130 was detectable in all three fractions, and the distribution pattern was in good accordance with that known for ONM/ER proteins. Interestingly, immunostaining of HeLa cells demonstrated nuclear rim staining of LRP130, specifically at the outside of the NE and also at ER, and association of LRP130 with poly(A)(+) RNA was restricted only to the ONM/ER fraction.
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Other Subcellular Localization: