Detail

RLID: RLID00002291
RNA Symbol: Actb
RNA Category: mRNA
Organism: Mus musculus
Aliase: Actx, E430023M04Rik, beta-actin
Sequence:
Homology: ACTB (Gallus gallus), ACTB (Homo sapiens)
Network:
Subcellular Localization:
Localization Tissue Validated Method PMID
Perinuclear MEF cell Florescence micrograph 26140598
Description: Next,we focused on the interaction in the cytoplasm, more specifically, the leading edge (Figure 2F, circle) and perinuclear regions (Figure 2F, square). In immortalized MEFs (Figures 2H and 2I), we found that ZBP1 bound b-actin mRNAs almost equally in both compartments (p > 0.1) (Figure 2J). These results provide a quantitative corroboration that ZBP1 binds b-actin mRNAs in the nuclear periphery and that phosphorylation of Y396F on ZBP1 leads to the release of the mRNA at the leading edge.

Other Subcellular Localization:

RLID Localization Tissue Validated Method PMID
RLID00002280 Cytoplasm Bone marrow Macrophage Next-generation sequencing 22817891
RLID00002281 Exosome Mast cell Microarray 17486113
RLID00002282 Growth cone Motoneuron In situ hybridization 14623865
RLID00002283 Endoplasmic reticulum MIN6 cell Northern blot 15972000
RLID00002284 Cytosol MIN6 cell Northern blot 15972000
RLID00002285 Dendrite Hippocampus In situ hybridization 16317045
RLID00002286 Ribosome S/S MEF cell RT-PCR 18195013
RLID00002287 Dendrite Neuron Fluorescence in situ hybridization 18539120
RLID00002288 Cell leading edge Fibroblast Fluorescence in situ hybridization 22832165
RLID00002289 Axon Soma qRT-PCR 24381269
RLID00002290 Cell leading edge MEF cell Florescence micrograph 26140598
RLID00002292 Axon Motoneuron In situ hybridization|qRT-PCR 26464439
RLID00002293 Somatodendritic compartment Motoneuron In situ hybridization|qRT-PCR 26464439
RLID00002294 Lamellipodium Migrating cell qRT-PCR 18451862
RLID00002295 Cell leading edge Migrating cell qRT-PCR 18451862