Detail
| RLID: | RLID00004256 |
| RNA Symbol: | Ins1 |
| RNA Category: | mRNA |
| Organism: | Mus musculus |
| Aliase: | Ins-1, Ins2-rs1 |
| Subcellular Localization: | |
| Localization | Tissue | Validated Method | PMID |
| Endoplasmic reticulum | INS-1 cell | qRT-PCR | 25018104 |
| Description: Preceding apoptosis, increasing ER stress agent levels progressively increases IRE1伪 phosphorylation, XBP1 mRNA splicing, endonucleolytic decay of the ER-localized mRNA, Ins1 mRNA (which encodes proinsulin), induction of thioredoxin-interacting protein (TXNIP) mRNA (whose product activates the NLRP3 inflammasome), and downstream c-Jun terminal kinase phosphorylation (JNKs) (Figure S1E,F). | |||
Other Subcellular Localization:
| RLID | Localization | Tissue | Validated Method | PMID |
| RLID00004257 | Endoplasmic reticulum | MIN6 cell | Northern blot | 15972000 |