Detail
| Localization |
Tissue |
Validated Method |
PMID |
| Nucleus |
Liver |
In situ hybridization |
2405055 |
|
Description: In normal rat liver, alb mRNA was expressed in all hepatocytes and was localized to discrete subcellular structures distributed as aggregates in the cytoplasm and in specific structures encircling the nucleus; these subcellular structures most likely represent the endoplasmic reticulum and nuclear envelope. Figure 3. In situ hybridization for albumin mRNA using aldehyde-fixed non-frozen sactions of rat liver, biotin-1 1-UTP anti-sense albumin RNA (riboprobe), and streptavidin-alkaline phosphatase detection system. (a, b) Biotinylated anti-sense alb RNA (riboprobe);(c)sense alb ANYcontrol probe. PT, portal triad; CV, central vein; N, nucleus. Albumin mANA is seen only in hepatocytes (a, b) and is shown as a diffuse cytoplasmic stain (arrows).
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Other Subcellular Localization: