Detail

RLID: RLID00008797
RNA Symbol: RNU11
RNA Category: snRNA
Organism: Homo sapiens
Aliase: RNU11-1, U11
Sequence:
Network:
Subcellular Localization:
Localization Tissue Validated Method PMID
Exosome Plasma Next-generation sequencing 23663360
Description: To annotate the exosomal RNA species that were not identified as miRNA transcripts, we first removed all the known miRNA sequences from the libraries and then mapped the remaining sequences to the human genome that had RNA annotations. Figure 5A shows the percentage of other small non-coding RNAs, tRNA, rRNA, small nuclear (snRNA), small nucleolar (snoRNA) and piwi-interacting RNA (piRNA) that were detected. The rRNA was the most common among them, accounting for 9.16% of all mappable counts, followed by piRNA (1.31%), tRNA (1.24%), snRNA (0.18%), and snoRNA (0.01%). Clearly, the exosomes contained relatively low levels of rRNA, which is in contrast to a typical eukaryotic cell where rRNA makes up at least 80% of the total RNA molecules. Interestingly, we also detected low levels of long RNA in the small RNA libraries. We detected 3.36% of long non-coding RNA (lncRNA), 1.36% of coding sequences (CDS), 0.54% of 3'untranslated region (UTR) and 0.21% of 5'UTR sequences [see Additional file 3]. Data are collected from Additional file 3: Top 20 RNAs in other RNA species (normalized to read number per million all mappable RNA seqeuences).

Other Subcellular Localization:

RLID Localization Tissue Validated Method PMID
RLID00008795 Exosome Breast cancer cell Next-generation sequencing 24255815
RLID00008796 Cytosol Colon cancer cell Next-generation sequencing 24393600
RLID00008798 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing 20498841