Detail

RLID: RLID00009344
RNA Symbol: H19
RNA Category: lncRNA
Organism: Homo sapiens
Aliase: ASM, ASM1, BWS, D11S813E, LINC00008, NCRNA00008, WT2
Sequence:
Network:
Subcellular Localization:
Localization Tissue Validated Method PMID
Ribosome Colon cancer cell Next-generation sequencing 24393600
Description: The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A.

Other Subcellular Localization:

RLID Localization Tissue Validated Method PMID
RLID00009338 Cytosol Myeloma cell qRT-PCR 21613539
RLID00009339 Cytoplasm Hepatoma cell Next generation sequencing 1688465
RLID00009340 Cytoplasm - lncRNAdb 25332394
RLID00009341 Circulating Plasma RT-PCR 23898077
RLID00009342 Nucleus Breast cancer cell qRT-PCR 18794369
RLID00009343 Nucleus - lncRNAdb 25332394
RLID00009345 Cytoplasm Brain Microarray 22955988