Detail
| RLID: |
RLID00015886 |
| RNA Symbol: |
TUG1 |
| RNA Category: |
lncRNA |
| Organism: |
Homo sapiens |
| Aliase: |
LINC00080, NCRNA00080, TI-227H |
| Subcellular Localization: |
| Localization |
Tissue |
Validated Method |
PMID |
| Nucleus |
HeLa cell|Kidney|Lung fibroblast |
In situ hybridizationq|RT-PCR |
22078878 |
|
Description: While Pc2 methylation appears to be the key determinant for relocation of growth control genes, based on a methylation/demethylation dependent switch in preference for TUG1 or NEAT2 interactions, respectively, we are tempted to speculate that other ncRNAs recognize covalent modifications of other gene-associated proteins, exerting their ncRNA scaffold functions in distinct subnuclear compartments to act as sensors for many regulated signaling pathways, and as modulators of 'reading' marks on histone tails for a variety of chromodomain-containing proteins and other histone code 'readers'.
|
Other Subcellular Localization: