Detail
| Localization |
Tissue |
Validated Method |
PMID |
| Nucleus |
Colon cancer cell |
Next-generation sequencing |
24393600 |
|
Description: The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A.
|
Other Subcellular Localization: