Detail
| RLID: |
RLID00021648 |
| RNA Symbol: |
XBP1 |
| RNA Category: |
mRNA |
| Organism: |
Homo sapiens |
| Aliase: |
TREB-5, TREB5, XBP-1, XBP2 |
| Homology: |
Xbp1 (Mus musculus
) |
| Subcellular Localization: |
| Localization |
Tissue |
Validated Method |
PMID |
| Nucleus |
MCF-7|293T|T47D |3T3 cell |
RT-PCR |
26068456 |
|
Description: Our results reveal the presence of basal unconventional splicing of XBP1 mRNA in the nucleus that also requires inositol-requiring transmembrane kinase and endonuclease 1a (IRE1a) and can occur independently of acute ER stress. Furthermore, we confirm that acute ER stress induces the splicing of XBP1 mRNA predominantly occurring in the cytoplasm, but it also promotes the splicing in the nucleus.
|
Other Subcellular Localization: