Detail

RLID:	RLID00023017
RNA Symbol:	CALR
RNA Category:	mRNA
Organism:	Homo sapiens
Aliase:	CRT, HEL-S-99n, RO, SSA, cC1qR
Sequence:
Homology:	Calr (Mus musculus), Calr (Rattus norvegicus )
Network:
Subcellular Localization:

Localization	Tissue	Validated Method	PMID
Ribosome	Colon cancer cell	Next-generation sequencing	24393600
Description: The RNA composition of the subcellular fractions differs significantly from each other, but lncRNAs are found in all locations. A subset of specific lncRNAs is enriched in the nucleus but surprisingly the majority is enriched in the cytosol and in ribosomal fractions. The ribosomal enriched lncRNAs include H19 and TUG1. Most studies on lncRNAs have focused on the regulatory function of these transcripts in the nucleus. We demonstrate that only a minority of all lncRNAs are nuclear enriched. Our findings suggest that many lncRNAs may have a function in cytoplasmic processes, and in particular in ribosome complexes. Data were collected from additional file 5: Table showing the normalized read counts for each cluster in Figure 4A.

Other Subcellular Localization:

RLID	Localization	Tissue	Validated Method	PMID
RLID00023018	Endoplasmic reticulum	T-cell line Jurkat	S1 nuclease protection assays	12923260
RLID00023019	Ribosome	T-cell line Jurkat	S1 nuclease protection assays	12923260
RLID00023020	Endoplasmic reticulum	HEK293 cell	Northern blot	21431749
RLID00023021	Ribosome	HeLa cell	qRT-PCR	25063809
RLID00023022	Ribosome	HEK293 cell	Next-generation sequencing	22199352
RLID00023023	Endoplasmic reticulum	COS-7 cell	Fluorescence in situ hybridization	22679391
RLID00023024	Endoplasmic reticulum	U2OS cell	RT-PCR	22679391
RLID00023025	Nucleus	COS-7 cell	Fluorescence in situ hybridization	22679391
RLID00023026	Endoplasmic reticulum	Myeloma cell	qRT-PCR	21613539
RLID00023027	Ribosome	Jurkat cell	Northern blot	12923260