Detail

RLID: RLID00027926
RNA Symbol: hsa-let-7a-5p
RNA Category: miRNA
Organism: Homo sapiens
Aliase: hsa-let-7a
Sequence:
Homology: aae-let-7 (Aedes aegypti), bta-let-7a-5p (Bos taurus)
Network:
Subcellular Localization:
Localization Tissue Validated Method PMID
Exosome Breast cancer cell Microarray 20976003
Description: Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2.

Other Subcellular Localization:

RLID Localization Tissue Validated Method PMID
RLID00027918 Circulating Plasma qRT-PCR 22262318
RLID00027919 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR 23525801
RLID00027920 Circulating Serum Next-generation sequencing|RT-PCR 23525801
RLID00027921 Circulating Serum Next-generation sequencing 23641832
RLID00027922 Circulating Plasma qRT-PCR 24937531
RLID00027923 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing 20498841
RLID00027924 Cytoplasm HeLa cell Microarray 21695135
RLID00027925 Exosome Serum Microarray 18589210
RLID00027927 Exosome Dendritic cell Microarray 21505438
RLID00027928 Exosome B cell Microarray 21505438
RLID00027929 Exosome Serum RT-PCR 22427800
RLID00027930 Exosome Brain tissue Microarray 23382797
RLID00027931 Exosome Plasma Next-generation sequencing 23663360
RLID00027932 Exosome Breast cancer cell RT-PCR|Microarray 24468161
RLID00027933 Exosome Esophageal cancer cell Next-generation sequencing 25184951
RLID00027934 Microvesicle Plasma qRT-PCR 19002258
RLID00027935 Microvesicle Glioblastoma cell qRT-PCR|Microarray 19011622
RLID00027936 Microvesicle Plasma Next-generation sequencing 23077538
RLID00027937 Microvesicle Seminal Plasma Microarray 23539611
RLID00027938 Microvesicle Hepatoma cell qRT-PCR|Microarray 23771658
RLID00027939 Mitochondrion HeLa cell Next-generation sequencing 22984580
RLID00027940 Mitochondrion Eembryonic kidney cell Next-generation sequencing 22984580
RLID00027941 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing 20498841
RLID00027942 Nucleus Colon adenocarcinoma cell Microarray 20864815
RLID00027943 Nucleus HeLa cell Next-generation sequencing 22058130
RLID00027944 Circulating Plasma Next-generation sequencing 25415674
RLID00027945 Nucleolus HeLa|MCF7 Microarray 24918059
RLID00027946 Exosome Serum Next-generation sequencing 24683445
RLID00027947 Exosome Plasma Next-generation sequencing 24683445
RLID00027948 Circulating Serum qRT-PCR 18766170
RLID00027949 Cytoplasm HeLa|MCF7 Microarray 24918059
RLID00027950 Nucleus HeLa|MCF7 Microarray 24918059
RLID00027951 Endoplasmic reticulum HEK293 cell Northern blo|RT-PCR 26304123
RLID00027952 Exosome Gastric cancer cell - 22529849
RLID00027953 Exosome Glioblastoma cell - 22529849
RLID00027954 Exosome Renal carcinomas cell - 22529849
RLID00027955 Circulating Serum Next-generation sequencing 22719975