Detail

RLID: RLID00028038
RNA Symbol: hsa-let-7d-5p
RNA Category: miRNA
Organism: Homo sapiens
Aliase: hsa-let-7d
Sequence:
Homology: aae-let-7 (Aedes aegypti), bta-let-7a-5p (Bos taurus)
Network:
Subcellular Localization:
Localization Tissue Validated Method PMID
Exosome Breast cancer cell Microarray 20976003
Description: Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2.

Other Subcellular Localization:

RLID Localization Tissue Validated Method PMID
RLID00028030 Circulating Plasma qRT-PCR 22262318
RLID00028031 Circulating Cerebrospinal fluid Next-generation sequencing|RT-PCR 23525801
RLID00028032 Circulating Serum Next-generation sequencing|RT-PCR 23525801
RLID00028033 Circulating Serum Next-generation sequencing 23641832
RLID00028034 Circulating Serum qRT-PCR|Next-generation sequencing 24577456
RLID00028035 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing 20498841
RLID00028036 Cytoplasm HeLa cell Microarray 21695135
RLID00028037 Exosome Serum Microarray 18589210
RLID00028039 Exosome Dendritic cell Microarray 21505438
RLID00028040 Exosome B cell Microarray 21505438
RLID00028041 Exosome Breast milk Next-generation sequencing 22211110
RLID00028042 Exosome Malignant melanoma cell Microarray 23056502
RLID00028043 Exosome Brain tissue Microarray 23382797
RLID00028044 Exosome Plasma Next-generation sequencing 23663360
RLID00028045 Exosome Breast cancer cell Microarray 24468161
RLID00028046 Exosome Mast cell Microarray 17486113
RLID00028047 Microvesicle Plasma Next-generation sequencing 23077538
RLID00028048 Microvesicle Seminal Plasma Microarray 23539611
RLID00028049 Microvesicle Follicular fluid Microarray 23666971
RLID00028050 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR 21637849
RLID00028051 Mitochondrion HeLa cell Next-generation sequencing 22984580
RLID00028052 Mitochondrion Eembryonic kidney cell Next-generation sequencing 22984580
RLID00028053 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing 20498841
RLID00028054 Nucleus Colon adenocarcinoma cell Microarray 20864815
RLID00028055 Nucleus HeLa cell Next-generation sequencing 22058130
RLID00028056 Circulating Plasma Next-generation sequencing 25415674
RLID00028057 Nucleolus HeLa|MCF7 Microarray 24918059
RLID00028058 Exosome Serum Next-generation sequencing 24683445
RLID00028059 Exosome Plasma Next-generation sequencing 24683445
RLID00028060 Cytoplasm HeLa|MCF7 Microarray 24918059
RLID00028061 Cytoplasm Colon cancer cell RT-PCR|Northern blot|Microarray 20864815
RLID00028062 Mitochondrion Myoblast In situ hybridization|qRT-PCR 21637849
RLID00028063 Exosome Gastric cancer cell - 22529849
RLID00028064 Circulating Serum Next-generation sequencing 22719975
RLID00028065 Exosome Mast cell Microarray 24009880