Detail
| RLID: |
RLID00028233 |
| RNA Symbol: |
hsa-miR-17-3p |
| RNA Category: |
miRNA |
| Organism: |
Homo sapiens |
| Aliase: |
hsa-miR-17-3p, hsa-miR-17* |
| Subcellular Localization: |
| Localization |
Tissue |
Validated Method |
PMID |
| Circulating |
Serum |
qRT-PCR |
22798503 |
|
Description: Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages.
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Other Subcellular Localization: