Detail

RLID: RLID00029369
RNA Symbol: hsa-miR-196a-5p
RNA Category: miRNA
Organism: Homo sapiens
Aliase: hsa-miR-196a
Sequence:
Homology: hsa-miR-196a-3p (Homo sapiens), hsa-miR-196b-3p (Homo sapiens)
Network:
Subcellular Localization:
Localization Tissue Validated Method PMID
Circulating Serum qRT-PCR 22798503
Description: Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages.

Other Subcellular Localization:

RLID Localization Tissue Validated Method PMID
RLID00029370 Cytoplasm Nasopharyngeal carcinoma cell Next-generation sequencing 20498841
RLID00029371 Exosome T cell Microarray 21505438
RLID00029372 Exosome Brain tissue Microarray 23382797
RLID00029373 Microvesicle Hepatoma cell qRT-PCR|Microarray 23771658
RLID00029374 Mitochondrion Skeletal muscular cell In situ hybridization|qRT-PCR 21637849
RLID00029375 Mitochondrion HeLa cell Next-generation sequencing 22984580
RLID00029376 Mitochondrion Eembryonic kidney cell Next-generation sequencing 22984580
RLID00029377 Nucleus Nasopharyngeal carcinoma cell Next-generation sequencing 20498841
RLID00029378 Nucleus HeLa cell Next-generation sequencing 22058130
RLID00029379 Cytoplasm HeLa|MCF7 Microarray 24918059
RLID00029380 Nucleus HeLa|MCF7 Microarray 24918059
RLID00029381 Microvesicle A549|HepG2 Microarrays|RT-PCR 20615901
RLID00029382 Exosome A549|HepG2 Microarrays|RT-PCR 20615901