Detail
| RLID: | RLID00032422 |
| RNA Symbol: | hsa-miR-424-5p |
| RNA Category: | miRNA |
| Organism: | Homo sapiens |
| Aliase: | hsa-miR-424 |
| Homology: | hsa-miR-424-3p (Homo sapiens), mmu-miR-322-3p (Mus musculus) |
| Subcellular Localization: | |
| Localization | Tissue | Validated Method | PMID |
| Exosome | Serum | Next-generation sequencing | 25349172 |
| Description: Deep sequencing of the exosomal RNA extracted from serum samples was performed and sequences were mapped to miRBase Exosomal miRNA biomarkers for Alzheimer's disease. Approximately half of the reads obtained (43%) from small RNA sequencing corresponded with miRNA sequences (Supplementary Table 1). Overall, the sample cohort mapped to 1419 known human miRNA sequences (Supplementary Table 2). Following normalisation of reads and performing ANOVA analyses, 17 miRNA were found to be significantly deregulated (Figure 1); 14 miRNA were found to be upregulated (hsa-miR-361-5p, hsa-miR-30e-5p, hsa-miR-93-5p, hsa-miR-15a-5p, hsa-miR-143-3p, hsa-miR-335-5p, hsa-miR-106b-5p, hsa-miR-101-3p, hsa-miR-424-5p, hsa-miR-106a-5p, hsa-miR-18b-5p, hsa-miR-3065-5p, hsa-miR-20a-5p and hsa-miR-582-5p) and three miRNA were found to be downregulated (hsa-miR-1306-5p, hsa-miR-342-3p and 15b-3p; Table 2). Data are collected from Table 2. | |||
Other Subcellular Localization:
| RLID | Localization | Tissue | Validated Method | PMID |
| RLID00032417 | Cytoplasm | Nasopharyngeal carcinoma cell | Next-generation sequencing | 20498841 |
| RLID00032418 | Exosome | Serum | Microarray | 18589210 |
| RLID00032419 | Exosome | Dendritic cell | Microarray | 21505438 |
| RLID00032420 | Exosome | Brain tissue | Microarray | 23382797 |
| RLID00032421 | Exosome | Plasma | Next-generation sequencing | 23663360 |
| RLID00032423 | Mitochondrion | Skeletal muscular cell | In situ hybridization|qRT-PCR | 21637849 |
| RLID00032424 | Mitochondrion | HeLa cell | Next-generation sequencing | 22984580 |
| RLID00032425 | Mitochondrion | Eembryonic kidney cell | Next-generation sequencing | 22984580 |
| RLID00032426 | Nucleus | Nasopharyngeal carcinoma cell | Next-generation sequencing | 20498841 |
| RLID00032427 | Nucleus | HeLa cell | Next-generation sequencing | 22058130 |
| RLID00032428 | Exosome | Serum | Next-generation sequencing | 24683445 |
| RLID00032429 | Exosome | Plasma | Next-generation sequencing | 24683445 |
| RLID00032430 | Nucleus | HeLa|MCF7 | Microarray | 24918059 |
| RLID00032431 | Circulating | Serum | Next-generation sequencing | 22719975 |