Detail
| RLID: | RLID00033815 |
| RNA Symbol: | hsa-miR-454-3p |
| RNA Category: | miRNA |
| Organism: | Homo sapiens |
| Aliase: | hsa-miR-454-3p, hsa-miR-454 |
| Homology: | hsa-miR-454-5p (Homo sapiens ) |
| Subcellular Localization: | |
| Localization | Tissue | Validated Method | PMID |
| Exosome | Breast cancer cell | Microarray | 20976003 |
| Description: Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2. | |||
Other Subcellular Localization:
| RLID | Localization | Tissue | Validated Method | PMID |
| RLID00033811 | Nucleus | HeLa cell | Next-generation sequencing | 22058130 |
| RLID00033812 | Circulating | Cerebrospinal fluid | Next-generation sequencing|RT-PCR | 23525801 |
| RLID00033813 | Exosome | Serum | Microarray | 18589210 |
| RLID00033814 | Exosome | Saliva | Microarray | 19627513 |
| RLID00033816 | Exosome | Dendritic cell | Microarray | 21505438 |
| RLID00033817 | Nucleolus | HeLa cell | qRT-PCR | 23940654 |
| RLID00033818 | Cytoplasm | HeLa|MCF7 | Microarray | 24918059 |
| RLID00033819 | Nucleus | HeLa|MCF7 | Microarray | 24918059 |
| RLID00033820 | Exosome | Saliva | - | 22529849 |