Detail

RLID: RLID00034329
RNA Symbol: hsa-miR-127-5p
RNA Category: miRNA
Organism: Homo sapiens
Sequence:
Homology: hsa-miR-127-3p (Homo sapiens), mmu-miR-127-3p (Mus musculus)
Subcellular Localization:
Localization Tissue Validated Method PMID
Circulating Serum qRT-PCR 22798503
Description: Our stem-loop RT-MGB qPCR in plasma and tissue samples from healthy individuals and patients with colon cancer presented in Table IV show that out of the 15 selected miRNAs exhibiting preferential expression and which have been shown to be related to colon carcinogenesis; nine of them (miR-7, miR-17-3p, miR-20a, miR-21, miR-92a, miR-96, miR-183, miR196a and miR-214) exhibited increased expression in plasma (and also in tissues) of patients with CRC, and that later TNM carcinoma stages had a more increased expression than did adenomas. On the other hand, six of the selected miRNAs (miR-124, miR-127-5p, miR-138, miR-143, miR-146a and miR-222) were reduced in expression in plasma (and also in tissues) of patients with CRC, the reduction becoming more pronounced during progression from early to later TNM carcinoma stages.

Other Subcellular Localization:

RLID Localization Tissue Validated Method PMID
RLID00034330 Exosome Plasma Next-generation sequencing 23663360
RLID00034331 Exosome B cell Next-generation sequencing 25242326
RLID00034332 Microvesicle Cerebrospinal fluid RNA-seq|miRDeep3 24797360