Detail

Localization	Tissue	Validated Method	PMID
Extracellular vesicle	HEK293T\|HMEC-1\|Mononuclear cell	Next-generation sequencing	22849433
Description: The total numbers of reads >15 bp matching each miRNA were calculated. These values were then normalized to number of reads per million mapped (RPMM) in each library, to enable direct comparison of expression levels. As a measure of the relative levels of expression of individual miRNAs in cells and EVs, the log (base two) of the ratio of the read number in EVs over that in cells was calculated (log2 (EV/cell)). The miRNA expression data for cells and EVs is presented in Additional file 1: Table S1. Data are collected from Table S1.

Other Subcellular Localization:

RLID	Localization	Tissue	Validated Method	PMID
RLID00035334	Circulating	Cerebrospinal fluid	Next-generation sequencing\|RT-PCR	23525801
RLID00035335	Circulating	Serum	Next-generation sequencing	23641832
RLID00035336	Circulating	Serum	Next-generation sequencing	24904649
RLID00035338	Exosome	Breast cancer cell	Microarray	20976003
RLID00035339	Exosome	Malignant melanoma cell	Microarray	23056502
RLID00035340	Circulating	Serum	Microarray	23169280
RLID00035341	Exosome	Plasma	Next-generation sequencing	23663360
RLID00035342	Mitochondrion	HeLa cell	Microarray	21695135
RLID00035343	Mitochondrion	HeLa cell	Next-generation sequencing	22984580
RLID00035344	Mitochondrion	Eembryonic kidney cell	Next-generation sequencing	22984580
RLID00035345	Nucleus	HeLa cell	Next-generation sequencing	22058130
RLID00035346	Exosome	Colon Cancer Cell Line	qRT-PCR\|RNA-seq	25330373
RLID00035347	Circulating	Serum	Microarray	24858071
RLID00035348	Exosome	Serum	Next-generation sequencing	24683445
RLID00035349	Mitochondrion	HeLa cell	Microarray\|RT-PCR	21695135
RLID00035350	Circulating	Serum	Next-generation sequencing	22719975