Detail

Localization	Tissue	Validated Method	PMID
Exosome	Breast cancer cell	Microarray	20976003
Description: Because of the suggested roles of extracellular miRNAs in signaling and diagnosis, we investigated whether the intracellular and extracellular miRNA composition are the same. To answer this question, we performed microRNA microarray analyses of MCF7 cellular (c) and extracellular (x) RNAs (Figure 2A), and found that about 66% of the released miRNAs are at an abundance that closely reflects the cellular miRNA abundance (Figures 2B and 2C). This finding is in agreement with a model wherein most, but not all miRNAs are released passively by mass action. Data are collected from Figure 2.

Other Subcellular Localization:

RLID	Localization	Tissue	Validated Method	PMID
RLID00035334	Circulating	Cerebrospinal fluid	Next-generation sequencing\|RT-PCR	23525801
RLID00035335	Circulating	Serum	Next-generation sequencing	23641832
RLID00035336	Circulating	Serum	Next-generation sequencing	24904649
RLID00035337	Extracellular vesicle	HEK293T\|HMEC-1\|Mononuclear cell	Next-generation sequencing	22849433
RLID00035339	Exosome	Malignant melanoma cell	Microarray	23056502
RLID00035340	Circulating	Serum	Microarray	23169280
RLID00035341	Exosome	Plasma	Next-generation sequencing	23663360
RLID00035342	Mitochondrion	HeLa cell	Microarray	21695135
RLID00035343	Mitochondrion	HeLa cell	Next-generation sequencing	22984580
RLID00035344	Mitochondrion	Eembryonic kidney cell	Next-generation sequencing	22984580
RLID00035345	Nucleus	HeLa cell	Next-generation sequencing	22058130
RLID00035346	Exosome	Colon Cancer Cell Line	qRT-PCR\|RNA-seq	25330373
RLID00035347	Circulating	Serum	Microarray	24858071
RLID00035348	Exosome	Serum	Next-generation sequencing	24683445
RLID00035349	Mitochondrion	HeLa cell	Microarray\|RT-PCR	21695135
RLID00035350	Circulating	Serum	Next-generation sequencing	22719975