Detail
| RLID: |
RLID00037036 |
| RNA Symbol: |
Xlsirt |
| RNA Category: |
lncRNA |
| Organism: |
Xenopus laevis |
| Subcellular Localization: |
| Localization |
Tissue |
Validated Method |
PMID |
| Mitochondrion |
Oocyte |
In situ hybridization |
8948579 |
|
Description: In the present study we analyzed the properties of the METRO pathway, which localizes Xlsirt, Xcat2, and Xwnt11 RNAs to a specific region of the vegetal cortex during stage 1 of oogenesis. A combination of methodologies involving both fixed material and living oocytes was used to analyze RNA localization. We show that in early diplotene pre-stage 1 oocytes (25-50 microm in diameter) both endogenous and injected exogenous METRO RNAs translocated to multiple mitochondrial aggregates (pre-mitochondrial clouds) that surround the germinal vesicle (GV). However, by early stage 1 (diplotene oocytes, 50-200 microm), all three of the RNAs discriminated between the different clouds and translocated exclusively within the METRO of a single mitochondrial cloud.
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Other Subcellular Localization: