Detail
| Localization |
Tissue |
Validated Method |
PMID |
| Perinuclear |
MEF cell |
Florescence micrograph |
26140598 |
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Description: Next,we focused on the interaction in the cytoplasm, more specifically, the leading edge (Figure 2F, circle) and perinuclear regions (Figure 2F, square). In immortalized MEFs (Figures 2H and 2I), we found that ZBP1 bound b-actin mRNAs almost equally in both compartments (p > 0.1) (Figure 2J). These results provide a quantitative corroboration that ZBP1 binds b-actin mRNAs in the nuclear periphery and that phosphorylation of Y396F on ZBP1 leads to the release of the mRNA at the leading edge.
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Other Subcellular Localization:
| RLID |
Localization |
Tissue |
Validated Method |
PMID |