Detail
| RLID: | RLID00017223 |
| RNA Symbol: | CORO1B |
| RNA Category: | mRNA |
| Organism: | Homo sapiens |
| Aliase: | CORONIN-2 |
| Subcellular Localization: | |
| Localization | Tissue | Validated Method | PMID |
| Lamellipodium | Endothelial cell | Immunocytochemistry | 23667561 |
| Description: Coronin 1B mRNA and protein are highly expressed in human pulmonary artery, umbilical vein, aortic and lung microvascular endothelial cells (Figure 1 A & B). Under normal growth conditions, as evidenced by immunocytochemistry, coronin 1B co-localizes with F-actin in a ?2 ?M thick region at the leading edge of the cell periphery (Figure 2). This is presumably the fast 鈥渢read-milling鈥?region of F-actin polymerization that has been well-characterized for cell lamellipodia. Furthermore, a significant fraction of coronin is also diffusely distributed within the cell cytoplasm, but this population of coronin does not co-localize with F-actin or cortactin. Upon serum starvation, coronin redistributes from the cell periphery and is distributed only within the cell cytosol (Figure 3). | |||
Other Subcellular Localization:
| RLID | Localization | Tissue | Validated Method | PMID |