Detail
| RLID: | RLID00037610 |
| RNA Symbol: | GGGGCC microsatellite repeat RNA |
| RNA Category: | mRNA |
| Organism: | Rattus norvegicus |
| Subcellular Localization: | |
| Localization | Tissue | Validated Method | PMID |
| Nucleus | Spinal cord neuron | In situ hybridization | 26650351 |
| Description: We confirmed that iPSNs contained nuclear GGGGCC RNA foci, but also found that 78 å¤ 12% SD (carrier 1; n=25 neurons) and 75 å¤ 11% SD (carrier 2; n=23) of iPSNs that contained nuclear GGGGCC RNA foci also contained neuritic GGGGCC RNA particles by in situ hybridization (Figure 1A,L). The GGGGCC RNA particles were detected both proximally and distally at over 45 æ¸m from the cell body in neurites and were, in some cases, lined up, consistent with possible association with a cytoskeletal track (Figure 1A-B). In addition, GGGGCC repeat RNA particles were detected in the cell body in nearly all iPSNs that also contained GGGGCC RNA nuclear foci (Figure 1C, also Almeida et al., 2013). | |||
Other Subcellular Localization:
| RLID | Localization | Tissue | Validated Method | PMID |