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Detail

Detail

RLID: RLID00006137
RNA Symbol: Hsp90b1
RNA Category: mRNA
Organism: Mus musculus
Aliase: ERp99, GRP94, TA-3, Targ2, Tra-1, Tra1, endoplasmin, gp96
Homology: Gp93 (Drosophila melanogaster), HSP90B1 (Homo sapiens )
Subcellular Localization:
Localization Tissue Validated Method PMID
Endoplasmic reticulum NIH-3T3 Fibroblast In situ hybridization 12923260
Description: For these experiments, three mRNAs were examined: that encoding GRP94, which is highly enriched in the ER membrane fraction of fractionated cells; GAPDH, which displays a predominately (but not uniquely) soluble enrichment; and Hsp90, which displays noncanonical partitioning on the ER. Experiments were performed using NIH-3T3 fibroblasts and digoxygenin-labeled antisense RNA probes, with optical sections obtained by widefield microscopy.As expected, mRNAs encoding GRP94 display a typical, perinuclear and reticular ER pattern (Fig. 6A), with the ImageJ rendering providing a graphical display of the perinuclear, ER partitioning of this mRNA species (Fig. 6A, far right panel).

Other Subcellular Localization:

RLID Localization Tissue Validated Method PMID