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Detail

Detail

RLID: RLID00008090
RNA Symbol: Hspa5
RNA Category: mRNA
Organism: Rattus norvegicus
Aliase: BIP, GRP78
Homology: Hspa5 (Mus musculus), Hspa5 (Rattus norvegicus)
Subcellular Localization:
Localization Tissue Validated Method PMID
Axon Neuron Fluorescence in situ hybridization 20308067
Description: MRNAs encoding the endoplasmic reticulum chaperone proteins calreticulin and Grp78/BiP were previously detected in sensory axons by RT-PCR and array hybridization (7, 30). Because these analyses used lysed axons that could contain proximal axonal segments, we used FISH to directly visualize the mRNAs in dissociated cultures of DRG neurons. DRG neurons showed punctate FISH signals for beta-actin, calreticulin, and Grp78/BiP mRNAs that extended into growth cones (Fig. 1A). This granular distribution is similar to other mRNAs localizing to dendrites and axons (21).mRNAs encoding the endoplasmic reticulum chaperone proteins calreticulin and Grp78/BiP were previously detected in sensory axons by RT-PCR and array hybridization (7, 30). Because these analyses used lysed axons that could contain proximal axonal segments, we used FISH to directly visualize the mRNAs in dissociated cultures of DRG neurons. DRG neurons showed punctate FISH signals for beta-actin, calreticulin, and Grp78/BiP mRNAs that extended into growth cones (Fig. 1A). This granular distribution is similar to other mRNAs localizing to dendrites and axons (21).

Other Subcellular Localization:

RLID Localization Tissue Validated Method PMID