Detail
| RLID: | RLID00000542 |
| RNA Symbol: | LRPPRC |
| RNA Category: | mRNA |
| Organism: | Homo sapiens |
| Aliase: | LSFC, GP130, LRP130, CLONE-23970 |
| Subcellular Localization: | |
| Localization | Tissue | Validated Method | PMID |
| Nucleus | HeLa cell | In situ hybridization | 15081402 |
| Description: To further analyze the subcellular localization of LRP130, a nuclear/ER fraction was fractionated into the nucleoplasm (NP) and nuclear envelope (NE)/ER, and the latter was further separated into outer nuclear membrane (ONM)/ER and inner nuclear membrane (INM) by treatment with Triton X-100. LRP130 was detectable in all three fractions, and the distribution pattern was in good accordance with that known for ONM/ER proteins. Interestingly, immunostaining of HeLa cells demonstrated nuclear rim staining of LRP130, specifically at the outside of the NE and also at ER, and association of LRP130 with poly(A)(+) RNA was restricted only to the ONM/ER fraction. | |||
Other Subcellular Localization:
| RLID | Localization | Tissue | Validated Method | PMID |