Detail
| RLID: | RLID00000404 |
| RNA Symbol: | Xbp1 |
| RNA Category: | mRNA |
| Organism: | Cricetulus griseus |
| Aliase: | I79_012500, Xbp-1 |
| Homology: | Paxbp1 (Mus musculus ) |
| Subcellular Localization: | |
| Localization | Tissue | Validated Method | PMID |
| Cytoplasm | Ovary cell | RT-PCR|Northern blot | 16644724 |
| Description: Using cell lines that continuously or transiently express these reporter constructs, we show that cytoplasmic unspliced XBP1 mRNA is efficiently spliced by activated IRE1alpha and requires ongoing cellular transcription but not active translation. Analysis of nuclear and cytoplasmic RNA fractions demonstrated that XBP1 mRNA splicing occurs in the cytoplasm. The results show that 5鈥?capped and 3鈥?poly(A)-tailed XBP1 mRNAs directly delivered into the cytoplasm can be efficient substrates for UPR-dependent XBP1 intron removal. | |||
Other Subcellular Localization:
| RLID | Localization | Tissue | Validated Method | PMID |