Detail
| RLID: | RLID00033238 |
| RNA Symbol: | rno-miR-494-3p |
| RNA Category: | miRNA |
| Organism: | Rattus norvegicus |
| Aliase: | rno-miR-494 |
| Subcellular Localization: | |
| Localization | Tissue | Validated Method | PMID |
| Mitochondrion | livers | qRT-PCR|Microarray | 19106625 |
| Description: Interestingly, miR-494 appears to be significantly enriched in mitochondria as its abundance in total RNA increased with purification as measured by qRT-PCR. To further define whether the miRNAs were present within the mitochondria, we used deoxycholic acid (DCA) to induce opening of the mitochondrial megapore channel33 and induction of the mitochondria permeability transition (MPT) in the isolated mitochondria.This disruption of mitochondrial integrity resulted in a significant loss of miRNAs by RT-PCR in the DCA treated mitochondria relative to the control vehicle group. The release of miR-130a and b, miR-320 and miR-494 was ~50% and that of miR-140 almost 80%. | |||
Other Subcellular Localization:
| RLID | Localization | Tissue | Validated Method | PMID |