All polymorphisms studied in this paper [PMID: 19134200] , total : 10 polymorphisms

Title : No evidence of major effects in several Toll-like receptor gene polymorphisms in rheumatoid arthritis.

Abstract : INTRODUCTION: The objective was to study the potential genetic contribution of Toll-like receptor (TLR) genes in rheumatoid arthritis (RA). TLRs bind to pathogen-associated molecular patterns, and TLR genes influence both proinflammatory cytokine production and autoimmune responses. Host-pathogen interactions are involved in RA physiopathology. METHODS: We tested SNPs of five TLR genes (TLR9, TLR2, TLR6, TLR1, and TLR4) in a cohort of 100 French families with RA. Genotypes were analyzed using the transmission disequilibrium test. As TLR2, TLR6, and TLR1 are located on chromosome 4, we determined the haplotype relative risk. Analyses were performed in subgroups defined by status for rheumatoid factor, anti-cyclic citrullinated peptide autoantibodies, and erosions. RESULTS: We found no disequilibrium in allele transmission for any of the SNPs of the five TLR genes. In subgroup analyses, no associations were detected linking TLR9, TLR2, or TLR9/TLR2 to rheumatoid factor, anti-cyclic citrullinated peptide autoantibodies, or erosions. Haplotype analysis of the polymorphisms showed no haplotype associations in any of the subgroups. CONCLUSIONS: We found no evidence of major effects of TLR gene polymorphisms in RA, although we tested different TLR phenotypes. Moreover, no associations were noted with autoantibody production or erosions.

Author : Jaen O,Petit-Teixeira E,Kirsten H,Ahnert P,Semerano L,Pierlot C,Cornelis F,Boissier MC,Falgarone G,

Source : Arthritis Res Ther. 2009;11(1):R5. doi: 10.1186/ar2589. Epub 2009 Jan 13.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs5743618	TLR1	7096
2	rs5743594	TLR1	7096
3	rs3804099	TLR2	7097
4	rs4696480	TLR2	7097
5	rs2737191	TLR4	7099
6	rs4986790	TLR4	7099
7	rs1554973	TLR4	7099
8	rs5743810	TLR6	10333
9	rs187084	TLR9	54106
10	rs352140	TLR9	54106