All polymorphisms studied in this paper [PMID: 15838509] , total : 35 polymorphisms

Title : A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities.

Abstract : Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis (odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-kappaB and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease-susceptible genotype. We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity.

Author : Kochi Y,Yamada R,Suzuki A,Harley JB,Shirasawa S,Sawada T,Bae SC,Tokuhiro S,Chang X,Sekine A,Takahashi A,Tsunoda T,Ohnishi Y,Kaufman KM,Kang CP,Kang C,Otsubo S,Yumura W,Mimori A,Koike T,Nakamura Y,Sasazuki T,Yamamoto K,

Source : Nat Genet. 2005 May;37(5):478-85. Epub 2005 Apr 17.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
31	rs2765503	CD5L	922
32	rs2297410	CD5L	922
33	rs2260040	CD5L	922
34	rs2281870	CD5L	922
35	rs3761958	NA	NA