All polymorphisms studied in this paper [PMID: 23378462] , total : 33 polymorphisms

Title : Replication of European rheumatoid arthritis loci in a Pakistani population.

Abstract : OBJECTIVE: Genetic studies have identified several rheumatoid arthritis (RA) susceptibility loci in European-derived populations. The same biological pathways may be involved in determining the RA risk in different population groups. We sought to replicate the association of 33 single-nucleotide polymorphisms (SNP) from 31 RA susceptibility loci confirmed among Europeans in a unique Pakistani population. METHODS: We genotyped 33 SNP in a sample of 366 Pakistanis that comprised related and unrelated cases and controls. Genotyping was performed using TaqMan assays and the results were analyzed with family case-control software. RESULTS: Twelve of the 33 SNP were replicated in this sample with significant p values ranging from 7.05E-06 to 3.72E-02, the most significant being the KIF5A-PIP4K2C/rs1678542 SNP. CONCLUSION: Our observations suggest that a number of RA susceptibility loci and related pathways are shared across different populations.

Author : Jalil SF,Bhatti A,Demirci FY,Wang X,Ahmed I,Ahmed M,Barmada MM,Malik JM,John P,Kamboh MI,

Source : J Rheumatol. 2013 Apr;40(4):401-7. doi: 10.3899/jrheum.121050. Epub 2013 Feb 1.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
31	rs4810485	CD40	958
32	rs3218253	IL2RB	3560
33	rs13315591	FAM107A	11170