All polymorphisms studied in this paper [PMID: 12508775] , total : 1 polymorphisms

Title : TNF +489 polymorphism does not contribute to susceptibility to rheumatoid arthritis.

Abstract : OBJECTIVES: To determine if a tumour necrosis factor (TNF +489) polymorphism is associated with susceptibility to rheumatoid arthritis (RA). METHODS: Two European populations were studied: 217 controls and 238 patients from the north of England and 145 controls and 179 patients from Spain. HLA-DRB1 and TNF +489 markers were typed using polymerase chain reaction based methods. RESULTS: Strong associations were demonstrated with shared epitope (SE) encoding HLA-DRB1 alleles in the English (OR = 2.9 [2.2-3.9]) and Spanish (OR = 2.3 [1.6-3.3]) populations, however no association was found with TNF +489 alleles. Furthermore carriage of TNF +489A was not associated with the presence of radiological erosions, rheumatoid nodules or rheumatoid factor. CONCLUSION: The role of the TNF locus in the genetic background of RA is unclear, however, our data does not support the previous reported association of the TNF +489A allele with RA susceptibility or severity.

Author : Low AS,Gonzalez-Gay MA,Akil M,Amos RS,Bax DE,Cannings C,Hajeer A,Till SH,Winfield J,Ollier WE,Wilson AG,

Source : Clin Exp Rheumatol. 2002 Nov-Dec;20(6):829-32.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	NA	TNF	7124