Title : FC gamma RIIa polymorphism in patients with rheumatoid arthritis. |
Abstract : OBJECTIVE: Polymorphism of phagocyte IgG receptor Fc gamma RIIa may modulate immune complex mediated inflammation, particularly when immune complex contain IgG2. METHODS: Fc gamma RIIa genotyping in 82 patients with rheumatoid arthritis (RA) and 148 healthy subjects was performed using the polymerase chain reaction technique with allele specific primers. RESULTS: No significant relation between Fc gamma RIIa genotypes and susceptibility to RA was observed, but extraarticular complications with high frequency were revealed in patients with R/R131 genotype. CONCLUSION: The results suggest that the Fc gamma RIIa polymorphism is not a risk factor for RA. |
Author : Pawlik A,Ostanek L,Brzosko I,Brzosko M,Fabrycy IF,Florczak M,Szklarz BG, |
Source : Clin Exp Rheumatol. 2002 Nov-Dec;20(6):841-4. |