All polymorphisms studied in this paper [PMID: 12649399] , total : 1 polymorphisms

Title : FcgammaRIIIA-158V and rheumatoid arthritis: a confirmation study.

Abstract : OBJECTIVES: To develop a robust assay for genotyping the FcgammaRIIIA-158V/F polymorphism and to confirm the putative association between the FcgammaRIIIA-158V allele and rheumatoid arthritis (RA). METHODS: This allelic association study examined the FcgammaRIIIA-158V/F polymorphism for association with RA. A novel single-stranded conformational polymorphism assay was used to genotype 828 RA patients and 581 controls from the UK. RESULTS: The FcgammaRIIIA-158V allele was associated with both RA (P=0.02) and nodules (P=0.04). Individuals homozygous for this higher affinity allele had a significantly increased risk of RA (OR 1.53, 95% CI 1.08-2.18) and the development of nodules (OR 2.20, 95% CI 1.20-4.01). There was no evidence of an interaction with the shared epitope. CONCLUSIONS: We have developed a novel assay to genotype the FcgammaRIIIA-158F/V polymorphism and confirmed that homozygosity for the FcgammaRIIIA-158V allele is associated with UK Caucasian RA, particularly in those individuals with nodules, suggesting FcgammaRIIIA may play a role in determining disease severity or in the development of nodules per se.

Author : Morgan AW,Keyte VH,Babbage SJ,Robinson JI,Ponchel F,Barrett JH,Bhakta BB,Bingham SJ,Buch MH,Conaghan PG,Gough A,Green M,Lawson CA,Pease CT,Markham AF,Ollier WE,Emery P,Worthington J,Isaacs JD,

Source : Rheumatology (Oxford). 2003 Apr;42(4):528-33.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs396991	FCGR3A	2214