All polymorphisms studied in this paper [PMID: 12730509] , total : 2 polymorphisms

Title : Association of polymorphisms of the tumour necrosis factor receptors I and II and rheumatoid arthritis.

Abstract : OBJECTIVE: To assess the role of polymorphisms of the tumour necrosis factor (TNF) receptors, TNF-RI (p55) and TNF-RII (p75) in the susceptibility to and severity of rheumatoid arthritis (RA) in Dutch patients. METHODS: A total of 319 consecutive RA patients, and a cohort of 90 female RA patients with detailed 12-yr follow-up were genotyped for the TNF-RI exon 1 (+36 A to G) and TNF-RII 3' UTR (+1690 T to C) polymorphisms. RESULTS: The frequencies of the TNF-RI and TNF-RII polymorphisms were determined in both patient groups and healthy controls, but no significant differences were found. To determine the relationship of these polymorphisms to disease severity, the extent of joint damage in the cohort of 90 female RA patients was analysed. No differences in severity were observed. CONCLUSION: These TNF-RI and TNF-RII polymorphisms were not found to be associated with susceptibility to or severity of RA in the Dutch population.

Author : Bayley JP,Bakker AM,Kaijzel EL,Huizinga TW,Verweij CL,

Source : Rheumatology (Oxford). 2003 Aug;42(8):969-71. Epub 2003 Mar 31.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs767455	TNFRSF1A	7132
2	rs3397	TNFRSF1B	7133