All polymorphisms studied in this paper [PMID: 12793199] , total : 7 polymorphisms

Title : The role of HLA-DRB1*04 alleles and their association with HLA-DQB genes in genetic susceptibility to rheumatoid arthritis in Hungarian patients.

Abstract : We investigated the HLA-DRB, and DQB polymorphism and haplotypes in RA subjects of Hungarian origin by PCR typing using sequence-specific primers. Molecular subtyping of HLA-DRB1*04 alleles in RA patients showed strongest association with highest relative risk with DRB1*0404. A significantly decreased frequency of DRB1*0403 was observed in patients compared to controls. A significant number of patients carried DR4 haplotypes on DQB1*0302 (54%) relative to DQB1*0301 which was present on 36% of the haplotypes. When compared to controls, the frequency was higher in the latter allele only. Few unique DRB-DQB haplotypes were observed in Hungarian RA patients. In spite of the fact, that the Hungarian population has been isolated linguistically over centuries, a considerable racial admixture has occurred following immigration and invasions, thus the present study confirms in Hungarian patients with RA, previous findings for RA and HLA in European countries.

Author : Varga E,Palkonyai E,Temesvari P,Toth F,Petri IB,

Source : Acta Microbiol Immunol Hung. 2003;50(1):33-41.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	NA	HLA-DRB1	3123
2	NA	HLA-DRB1	3123
3	NA	HLA-DRB1	3123
4	NA	HLA-DRB1	3123
5	NA	HLA-DRB1	3123
6	NA	HLA-DRB1	3123
7	NA	HLA-DRB1	3123