All polymorphisms studied in this paper [PMID: 15759012] , total : 1 polymorphisms

Title : Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases.

Abstract : A functional single nucleotide polymorphism, 1858C>T, in the PTPN22 gene, encoding a tyrosine phosphatase, has been reported to be associated with type I diabetes and some other autoimmune diseases. To further investigate whether this polymorphism may be a general susceptibility factor for autoimmunity, we performed an association study in five different autoimmune diseases, three previously not tested. We found an association with juvenile idiopathic arthritis (OR=1.41; P=0.04), not previously reported, and a tendency for an association with coeliac disease (OR=1.35; P=0.08). In primary sclerosing cholangitis, no association was observed (OR=0.95; P=0.8). Furthermore, we confirmed the increased risk in rheumatoid arthritis (OR=1.58; P=0.001), but could not find support for an association with systemic lupus erythematosus (OR=0.94; P=0.8). Altogether, we have provided further evidence of an association between autoimmune diseases and the 1858C>T polymorphism in PTPN22.

Author : Viken MK,Amundsen SS,Kvien TK,Boberg KM,Gilboe IM,Lilleby V,Sollid LM,Forre OT,Thorsby E,Smerdel A,Lie BA,

Source : Genes Immun. 2005 May;6(3):271-3.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs2476601	PTPN22	26191