All polymorphisms studied in this paper [PMID: 15794197] , total : 5 polymorphisms

Title : TGF-beta1 polymorphism determines the progression of joint damage in rheumatoid arthritis.

Abstract : OBJECTIVE: To determine whether transforming growth factor-beta1 (TGF-beta1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) and to analyse whether they can affect the progression of radiographic severity. METHODS: A total of 143 RA patients and 148 healthy unrelated controls were tested for the TGF-beta1 polymorphisms using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). RESULTS: The TGF-beta1 polymorphisms were not associated with susceptibility to RA, although there was a trend that -509C/T and the 869T/C polymorphisms were associated with RA in the male population. The progression of radiographic severity, which was defined by a modified Sharp score plotted against disease duration, was significantly faster in the carrier of T allele at the -509 (p=0.048). CONCLUSION: Our data support the hypothesis that TGF-beta1 polymorphism may determine the progression of joint destruction in RA.

Author : Kim SY,Han SW,Kim GW,Lee JM,Kang YM,

Source : Scand J Rheumatol. 2004;33(6):389-94.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	NA	TGFB1	7040
2	NA	TGFB1	7040
3	rs1982073	TGFB1	7040
4	NA	TGFB1	7040
5	NA	TGFB1	7040