All polymorphisms studied in this paper [PMID: 15838509] , total : 35 polymorphisms

Title : A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities.

Abstract : Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis (odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-kappaB and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease-susceptible genotype. We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity.

Author : Kochi Y,Yamada R,Suzuki A,Harley JB,Shirasawa S,Sawada T,Bae SC,Tokuhiro S,Chang X,Sekine A,Takahashi A,Tsunoda T,Ohnishi Y,Kaufman KM,Kang CP,Kang C,Otsubo S,Yumura W,Mimori A,Koike T,Nakamura Y,Sasazuki T,Yamamoto K,

Source : Nat Genet. 2005 May;37(5):478-85. Epub 2005 Apr 17.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs3811037	FCRL5	83416
2	rs3811036	FCRL5	83416
3	rs3811035	FCRL5	83416
4	rs3811034	FCRL5	83416
5	rs3811033	FCRL5	83416
6	rs3811032	FCRL5	83416
7	rs3761961	FCRL5	83416
8	rs849828	FCRL4	83417
9	rs849827	FCRL4	83417
10	rs2777962	FCRL4	83417
11	rs1885560	FCRL4	83417
12	rs1361889	FCRL4	83417
13	rs2282283	FCRL3	115352
14	rs2282284	FCRL3	115352
15	rs2210913	FCRL3	115352
16	rs3761959	FCRL3	115352
17	rs945635	FCRL3	115352
18	rs11264799	FCRL3	115352
19	rs7528684	FCRL3	115352
20	rs2225828	FCRL3	115352
21	rs10158440	FCRL3	115352
22	rs7552639	NA	NA
23	rs3818813	FCRL2	79368
24	rs2275232	FCRL2	79368
25	rs7546211	FCRL2	79368
26	rs3811024	FCRL1	115350
27	rs2050568	FCRL1	115350
28	rs4971154	FCRL1	115350
29	rs2765500	CD5L	922
30	rs2261295	CD5L	922