All polymorphisms studied in this paper [PMID: 17532759] , total : 3 polymorphisms

Title : Glucocorticoid receptor gene polymorphisms and susceptibility to rheumatoid arthritis.

Abstract : BACKGROUND: A defect in hypothalamic-pituitary-adrenal (HPA) axis function has been suggested to contribute to susceptibility to rheumatoid arthritis (RA). OBJECTIVE: To investigate polymorphisms of the glucocorticoid receptor (GR) gene and determine any associations with RA. METHODS: Three GR polymorphisms that tag 95% of all haplotypes across the GR gene were genotyped. These are an intron B Bcl1 polymorphism, a ttg insertion/deletion within intron F (rs2307674) and the single nucleotide polymorphism (SNP) lying in the 3' untranslated region of exon 9b (rs6198). The dye terminator-based SNaPshot method or size resolution by capillary electrophoresis was performed. The study population comprised 198 UK Caucasian RA cases and 393 ethnically matched controls. RESULTS: No significant single point or haplotypic associations were found for GR polymorphisms with RA susceptibility. Furthermore, no evidence for GR polymorphisms with aspects of RA severity was seen. CONCLUSION: In this study of the most comprehensive coverage of GR polymorphisms with RA, no significant contributing role for GR polymorphisms with RA was found.

Author : Donn R,Payne D,Ray D,

Source : Clin Endocrinol (Oxf). 2007 Sep;67(3):342-5. Epub 2007 May 28.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	NA	NR3C1	2908
2	rs2307674	NR3C1	2908
3	rs6198	NR3C1	2908