All polymorphisms studied in this paper [PMID: 17616399] , total : 13 polymorphisms

Title : Molecular screening and association study of IL15 gene polymorphisms in rheumatoid arthritis.

Abstract : Interleukin 15 (IL-15) is a pleiotropic pro-inflammatory cytokine known to play a relevant role in rheumatoid arthritis (RA) pathogenesis. In this study we aimed to investigate for the first time the contribution of IL15 gene to RA susceptibility. We screened 13 single nucleotide polymorphisms (SNPs) localised within IL15 regulatory regions (promoter, 5' UTR region and 3' UTR region) in a total of 420 individuals, who were genotyped by direct sequencing of PCR products. In addition, an association study of these IL15 SNPs was conducted in three independent case-control cohorts of Spanish Caucasian origin, including a total of 645 RA patients and 656 healthy controls. The presence of the 13 selected IL15 SNPs in our population was confirmed and no new genetic variants were found. The distribution of the IL15 selected SNPs in RA patients and controls showed no statistically significant deviation in any of the populations studied. Additionally, we performed a haplotype analysis that revealed three IL15 haplotype blocks. None of the haplotype blocks was associated with RA susceptibility or severity in the three cohorts analysed. Our results suggest that the IL15 gene polymorphisms do not appear to play a major role in RA genetic predisposition in our population.

Author : Rueda B,Lopez-Nevot MA,Gonzalez-Gay MA,Balsa A,Pascual-Salcedo D,Garcia A,Gonzalez A,Martin J,

Source : Cytokine. 2007 May;38(2):84-9. Epub 2007 Jul 5.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs4956403	IL15	3600
2	rs3806798	IL15	3600
3	rs7440292	IL15	3600
4	rs1493012	IL15	3600
5	rs1493013	IL15	3600
6	rs2254514	IL15	3600
7	rs2857261	IL15	3600
8	rs9282741	IL15	3600
9	rs9282742	IL15	3600
10	rs1057972	IL15	3600
11	rs9282743	IL15	3600
12	rs10833	IL15	3600
13	rs2291596	IL15	3600