All polymorphisms studied in this paper [PMID: 17678723] , total : 5 polymorphisms

Title : Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort.

Abstract : Recently, a genome-wide association study identified the interleukin-23 receptor gene (IL23R) as an inflammatory bowel disease (IBD) associated gene. Given the involvement of IL23R in T-cell regulation, we decided to test whether this gene is associated with rheumatoid arthritis (RA). Eight IL23R gene polymorphisms (rs1,004,819, rs7,517,847, rs10,489,629, rs11,209,026, rs1,343,151, rs10,889,677, rs11,209,032, and rs1,495,965) were selected among the 10 most associated SNPs from the IBD study. A total of 322 RA patients and 342 healthy controls were genotyped for the selected SNPs using a Taqman 5' allelic discrimination assay. We did not find statistically significant differences when we compared allele and genotype frequencies between RA patients and controls for none of the IL23R gene polymorphisms under study. We did not observe significant differences when RA patients were stratified according to their clinical and demographic features. We conclude that the IL23R gene does not seem to be associated with RA predisposition in a Spanish population.

Author : Orozco G,Rueda B,Robledo G,Garcia A,Martin J,

Source : Hum Immunol. 2007 Aug;68(8):681-4. Epub 2007 Jun 19.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs1004819	IL23R	149233
2	rs7517847	IL23R	149233
3	rs1343151	IL23R	149233
4	rs10889677	IL23R	149233
5	rs11209032	NA	NA