All polymorphisms studied in this paper [PMID: 17899094] , total : 1 polymorphisms

Title : The -844 G/A PAI-1 polymorphism is associated with mRNA expression in rheumatoid arthritis.

Abstract : We assessed whether the -844 G/A polymorphism and mRNA expression of plasminogen activator inhibitor 1 (PAI-1) gene are associated with rheumatoid arthritis (RA). Demographic data, hematological, biochemical parameters, disease activity-disability indexes, -844 G/A genotypes and mRNA expression levels of the PAI-1 gene were determined in 50 RA patients and 50 healthy subjects (HS). Non-significant differences in genotype and allele frequencies related to -844 G/A polymorphism in RA versus HS, were found. High mRNA expression of the PAI-1 gene, was demonstrated in RA versus HS (P < 0.05). In addition, A/A genotype carriers showed increase of PAI-1 mRNA expression (3.1-fold) respect to G/G and G/A genotypes in RA patients (P < 0.05). Our finding suggest an association of A/A -844 PAI-1 genotype with high PAI-1 mRNA expression in RA patients.

Author : Torres-Carrillo NM,Torres-Carrillo N,Vazquez-Del Mercado M,Delgado-Rizo V,Oregon-Romero E,Parra-Rojas I,Munoz-Valle JF,

Source : Rheumatol Int. 2008 Feb;28(4):355-60. Epub 2007 Sep 26.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	NA	SERPINE1	5054