All polymorphisms studied in this paper [PMID: 17999365] , total : 2 polymorphisms

Title : Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.

Abstract : Recently, association of celiac disease with common single-nucleotide polymorphism (SNP) variants in an extensive linkage-disequilibrium block of 480 kb containing the KIAA1109, Tenr, IL2, and IL21 genes has been demonstrated in three independent populations (rs6822844P combined=1.3 x 10(-14)). The KIAA1109/Tenr/IL2/IL21 block corresponds to the Idd3 locus in the nonobese diabetic mouse model of type 1 diabetes (T1D). This block was recently found to be associated with T1D in a genomewide association study, although this finding lacks unequivocal confirmation. We therefore aimed to investigate whether the KIAA1109/Tenr/IL2/IL21 region is involved in susceptibility to multiple autoimmune diseases. We tested SNP rs6822844 for association with disease in 350 T1D-affected and 1,047 rheumatoid arthritis (RA)-affected Dutch patients and in 929 controls. We replicated the association with T1D (P=.0006; OR 0.64 [95% CI 0.50-0.83]), and revealed a similar novel association with RA (P=.0002; OR 0.72 [95% CI 0.61-0.86]). Our results replicate and extend the association found in the KIAA1109/Tenr/IL2/IL21 gene region with autoimmune diseases, implying that this locus is a general risk factor for multiple autoimmune diseases.

Author : Zhernakova A,Alizadeh BZ,Bevova M,van Leeuwen MA,Coenen MJ,Franke B,Franke L,Posthumus MD,van Heel DA,van der Steege G,Radstake TR,Barrera P,Roep BO,Koeleman BP,Wijmenga C,

Source : Am J Hum Genet. 2007 Dec;81(6):1284-8. Epub 2007 Oct 24.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs6822844	NA	NA
2	rs4505848	KIAA1109	84162