All polymorphisms studied in this paper [PMID: 18006541] , total : 8 polymorphisms

Title : Genetic variations in the serotonin 5-HT2A receptor gene (HTR2A) are associated with rheumatoid arthritis.

Abstract : OBJECTIVES: To analyse the association between the genetic polymorphisms within the HTR2A gene for the serotonin receptor and rheumatoid arthritis (RA). METHODS: HTR2A gene polymorphisms were analysed in patients with RA and controls from two study populations using PCR based restriction endonuclease mapping or TaqMan allelic discrimination with more than 4000 individuals included in the current study. RESULTS: At the discovery stage we detected significant differences in frequency of rs6313 (T102C polymorphism) between the patients with RA and controls (p = 0.006). Following validation with an extended set of single nucleotide polymorphisms (SNPs) and number of DNA samples, a trend in associations in allelic model for SNPs rs6314, rs1328674, rs6313 and rs6311 (p = 0.006, 0.002, 0.006, 0.009) was seen, although it was lost after correction for multi-comparison for all but rs1328674 (empirical p value = 0.021). However, haplotype frequency analysis based on these four SNPs showed significantly low representation of TCTT combination in patients with RA in comparison with controls (3.6% and 5.6%, p<0.001 on chi(2) test, empirical p = 0.004 after 100 000 permutations) and a significantly higher frequency of CTCC combination in patients with RA in comparison with controls (3.6% and 2.2%, p = 0.002 on chi(2) test, empirical p = 0.022 after 100 000 permutations). CONCLUSIONS: In our study, genetic polymorphisms at the HTR2A gene are associated with susceptibility for RA, suggesting possible links between the serotonergic system and development of the disease.

Author : Kling A,Seddighzadeh M,Arlestig L,Alfredsson L,Rantapaa-Dahlqvist S,Padyukov L,

Source : Ann Rheum Dis. 2008 Aug;67(8):1111-5. Epub 2007 Nov 15.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs6313	HTR2A	3356
2	rs6314	HTR2A	3356
3	rs7997012	HTR2A	3356
4	rs977003	HTR2A	3356
5	rs1328674	HTR2A	3356
6	rs2070037	HTR2A	3356
7	rs2070040	HTR2A	3356
8	rs6311	HTR2A	3356