All polymorphisms studied in this paper [PMID: 18625033] , total : 6 polymorphisms
| Title : Polymorphisms in the selenoprotein S gene: lack of association with autoimmune inflammatory diseases. |
| Abstract : BACKGROUND: Selenoprotein S (SelS) protects the functional integrity of the endoplasmic reticulum against the deleterious effects of metabolic stress. SEPS1/SelS polymorphisms have been involved in the increased release of pro-inflammatory cytokines interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and IL-6 in macrophages. We aimed at investigating the role of the SEPS1 variants previously associated with higher plasma levels of these cytokines and of the SEPS1 haplotypes in the susceptibility to develop immune-mediated diseases characterized by an inflammatory component. RESULTS: Six polymorphisms distributed through the SEPS1 gene (rs11327127, rs28665122, rs4965814, rs12917258, rs4965373 and rs2101171) were genotyped in more than two thousand patients suffering from type 1 diabetes, rheumatoid arthritis or inflammatory bowel diseases and 550 healthy controls included in the case-control study. CONCLUSION: Lack of association of SEPS1 polymorphisms or haplotypes precludes a major role of this gene increasing predisposition to these inflammatory diseases. |
| Author : Martinez A,Santiago JL,Varade J,Marquez A,Lamas JR,Mendoza JL,de la Calle H,Diaz-Rubio M,de la Concha EG,Fernandez-Gutierrez B,Urcelay E, |
| Source : BMC Genomics. 2008 Jul 14;9:329. doi: 10.1186/1471-2164-9-329. |
6 records 1/1 page
| No. | Polymorphism name | Gene Symbol | Entrez Gene ID |
|---|---|---|---|
| 1 | rs11327127 | VIMP | 55829 |
| 2 | rs28665122 | VIMP | 55829 |
| 3 | rs4965814 | VIMP | 55829 |
| 4 | rs12917258 | VIMP | 55829 |
| 5 | rs4965373 | VIMP | 55829 |
| 6 | rs2101171 | NA | NA |
6 records 1/1 page
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