All polymorphisms studied in this paper [PMID: 19004047] , total : 1 polymorphisms

Title : Association between the aggrecan gene and rheumatoid arthritis.

Abstract : OBJECTIVE: Genetic and environmental factors seem to be involved in the onset of rheumatoid arthritis (RA). We analyzed whether a variable number of tandem repeats (VNTR) polymorphism in the aggrecan gene was associated to RA. METHODS: The study population comprised 170 European-derived Brazilian patients with diagnosis of RA. The control group comprised 148 European-derived Brazilian healthy blood donors. The aggrecan VNTR polymorphism was genotyped by DNA amplification by polymerase chain reaction, followed by electrophoresis in polyacrylamide gel. RESULTS: There was a statistically significant higher frequency of alleles of shorter length in the patient group compared to controls (p = 0.001), suggesting that individuals carrying short alleles are more likely to develop RA. There was no association between short alleles and clinical characteristics of RA. CONCLUSION: Our results provide evidence of an association between the aggrecan gene VNTR polymorphism and RA.

Author : de Souza TB,Mentz EF,Brenol CV,Xavier RM,Brenol JC,Chies JA,Simon D,

Source : J Rheumatol. 2008 Dec;35(12):2325-8. doi: 10.3899/jrheum.071326. Epub 2008 Nov 1.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	NA	ACAN	176