All polymorphisms studied in this paper [PMID: 19030862] , total : 1 polymorphisms

Title : The Val762Ala polymorphism in the poly(ADP-ribose) polymerase-1 gene is not associated with susceptibility in Turkish rheumatoid arthritis patients.

Abstract : The findings of the studies on poly(ADP-ribose) polymerase-1 (PARP-1) have suggested that the enzyme inactivation provides significant protection against systemic or tissue inflammation in animal models. It has also shown that the single-nucleotide polymorphism (Val762Ala) of the PARP-1 causes about 40% decrease of enzyme activity. The aim of this study was to analyze the association of the PARP-1 Val762Ala polymorphism in Turkish patients with rheumatoid arthritis. A total of 128 RA patients and 165 normal controls from the same geographic region were studied and polymerase chain reaction (PCR)-based restriction analysis was used to identify Val762Ala polymorphism of the PARP-1. Association analyses were performed using chi (2) tests. Our results indicated that the distribution of the PARP-1 genotypes and alleles did not differ significantly among subjects with or without RA (P > 0.05). The results of the study indicate that, for our Turkish sample, the V762A polymorphism of the PARP-1 may not be involved in susceptibility to RA, implying that the polymorphism may not function as a candidate gene marker for screening RA patients.

Author : Onaran I,Tezcan G,Ozgonenel L,Cetin E,Ozdemir AT,Kanigur-Sultuybek G,

Source : Rheumatol Int. 2009 May;29(7):797-800. doi: 10.1007/s00296-008-0772-8. Epub 2008 Nov 22.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs1136410	PARP1	142