All polymorphisms studied in this paper [PMID: 19034457] , total : 7 polymorphisms

Title : Lack of association between interleukin 23 receptor gene polymorphisms and rheumatoid arthritis susceptibility.

Abstract : The recent discovery of interleukin 23 (IL-23), its receptor, and the underlying signal transduction pathway has improved our understanding of cellular immunity. Several studies suggest that IL-23 is an essential promoter of chronic joint inflammation. In this report, we assess the possible association of interleukin 23 receptor (IL23R) polymorphisms and haplotypes with rheumatoid arthritis (RA). The study was conducted on 1,204 RA patients and 979 healthy controls. Seven polymorphisms were selected from previous IBD reports. The seven SNPs (rs1004819, rs7517847, rs10489629, rs2201841, rs1343151, rs11209032 and rs1495965) were genotyped using the TaqMan assay. Comparison of RA and control subjects revealed no statistically significant differences in the distribution of the IL23R genotypes and haplotypes. Our results clearly indicate that IL23R gene polymorphisms do not play a significant role in susceptibility to RA in the Korean population. Accordingly, we conclude that IL23R gene polymorphisms cannot be applied as an effective genetic marker for RA susceptibility.

Author : Park JH,Kim YJ,Park BL,Bae JS,Shin HD,Bae SC,

Source : Rheumatol Int. 2009 May;29(7):781-6. doi: 10.1007/s00296-008-0770-x. Epub 2008 Nov 26.

No.	Polymorphism name	Gene Symbol	Entrez Gene ID
1	rs1004819	IL23R	149233
2	rs7517847	IL23R	149233
3	rs10489629	IL23R	149233
4	rs2201841	IL23R	149233
5	rs1343151	IL23R	149233
6	rs11209032	NA	NA
7	rs1495965	NA	NA